Automated DBS microsampling, microscale automation and microflow LC-MS for therapeutic protein PK.
Zhang, Qian; Tomazela, Daniela; Vasicek, Lisa A; Spellman, Daniel S; Beaumont, Maribel; Shyong, BaoJen; Kenny, Jacqueline; Fauty, Scott; Fillgrove, Kerry; Harrelson, Jane; Bateman, Kevin P.
; 8(7): 649-59, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26977979
Nanoporous Gyroid-Structured Epoxy from Block Copolymer Templates for High Protein Adsorbability.
Challenges and opportunities in mass spectrometric analysis of proteins from dried blood spots.
Pharmacokinetic modeling of the subcutaneous absorption of therapeutic proteins.
Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited.
Enantioseparation and determination of asenapine in biological fluid micromatrices by HPLC with diode array detection.
Surfactant-aided precipitation/on-pellet-digestion (SOD) procedure provides robust and rapid sample preparation for reproducible, accurate and sensitive LC/MS quantification of therapeutic protein in plasma and tissues.
Pharmacological considerations for predicting PK/PD at the site of action for therapeutic proteins.
(14)C radiolabeling of proteins to monitor biodistribution of ingested proteins.
Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.
Direct Tissue Profiling of Protein Complexes: Toward Native Mass Spectrometry Imaging.