Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates.

Kern, Jeffrey C; Cancilla, Mark; Dooney, Deborah; Kwasnjuk, Kristen; Zhang, Rena; Beaumont, Maribel; Figueroa, Isabel; Hsieh, SuChun; Liang, Linda; Tomazela, Daniela; Zhang, Jeffrey; Brandish, Philip E; Palmieri, Anthony; Stivers, Peter; Cheng, Mangeng; Feng, Guo; Geda, Prasanthi; Shah, Sanjiv; Beck, Andrew; Bresson, Damien; Firdos, Juhi; Gately, Dennis; Knudsen, Nick; Manibusan, Anthony; Schultz, Peter G; Sun, Ying; Garbaccio, Robert M.
J Am Chem Soc; 138(4): 1430-45, 2016 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-26745435