Autophagy is essential for effector CD8(+) T cell survival and memory formation.
Xu, Xiaojin; Araki, Koichi; Li, Shuzhao; Han, Jin-Hwan; Ye, Lilin; Tan, Wendy G; Konieczny, Bogumila T; Bruinsma, Monique W; Martinez, Jennifer; Pearce, Erika L; Green, Douglas R; Jones, Dean P; Virgin, Herbert W; Ahmed, Rafi.
; 15(12): 1152-61, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25362489
Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8<sup>+</sup> T Cells.
T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells.
Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.
T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
The transcription factor c-Myb regulates CD8<sup>+</sup> T cell stemness and antitumor immunity.
B cell depletion curtails CD4+ T cell memory and reduces protection against disseminating virus infection.
IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection.
Host genetics play a critical role in controlling CD8 T cell function and lethal immunopathology during chronic viral infection.
Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory.