Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment.
Mattos, Katherine A; Oliveira, Viviane C G; Berrêdo-Pinho, Marcia; Amaral, Julio J; Antunes, Luis Caetano M; Melo, Rossana C N; Acosta, Chyntia C D; Moura, Danielle F; Olmo, Roberta; Han, Jun; Rosa, Patricia S; Almeida, Patrícia E; Finlay, B Brett; Borchers, Christoph H; Sarno, Euzenir N; Bozza, Patricia T; Atella, Georgia C; Pessolani, Maria Cristina V.
; 16(6): 797-815, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24552180
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
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Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation.
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Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.