Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin.
Khan, Sanaullah; Nan, Ruodan; Gor, Jayesh; Mulloy, Barbara; Perkins, Stephen J.
; 444(3): 417-28, 2012 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-22471560
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.
Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.
Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.
The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.
The development of atypical hemolytic uremic syndrome depends on complement C5.
Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration.
Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates.
Hiding in plain sight: immune evasion by the staphylococcal protein SdrE.