The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.
Ahmed, Neesar; Zeng, Minghui; Sinha, Indrajit; Polin, Lisa; Wei, Wei-Zen; Rathinam, Chozhavendan; Flavell, Richard; Massoumi, Ramin; Venuprasad, K.
; 12(12): 1176-83, 2011 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-22057290
Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.
Transcriptional Addiction in Cancer.
Putting p53 in Context.
A histone modifier's ill-gotten copy gains.
Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.
Adoptive immunotherapy for cancer or viruses.
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.
Coming full circle-from endless complexity to simplicity and back again.
Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer.
Metabolic regulation of T lymphocytes.