Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors.
Zificsak, Craig A; Theroff, Jay P; Aimone, Lisa D; Angeles, Thelma S; Albom, Mark S; Cheng, Mangeng; Mesaros, Eugen F; Ott, Gregory R; Quail, Matthew R; Underiner, Ted L; Wan, Weihua; Dorsey, Bruce D.
Bioorg Med Chem Lett
; 21(13): 3877-80, 2011 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-21632243
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold.
Cyclometalated Gold(III) Complexes Bearing DACH Ligands.
Synthesis of novel spiro[pyrazolo[4,3-d]pyrimidinones and spiro[benzo[4,5]thieno[2,3-d]pyrimidine-2,3'-indoline]-2',4(3H)-diones and their evaluation for anticancer activity.
Design, synthesis of novel pyranotriazolopyrimidines and evaluation of their anti-soybean lipoxygenase, anti-xanthine oxidase, and cytotoxic activities.
Design, synthesis and biological evaluation of sulfonamide-substituted diphenylpyrimidine derivatives (Sul-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with antitumor activity.
Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.
Structure-guided design of anti-cancer ribonucleotide reductase inhibitors.
[Design, synthesis and biological evaluation of novel para-substituted 1-benzyl-quinazoline-2, 4 (1H, 3H)-diones as human PARP-1 inhibitors].
Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity.
Synthesis and anticancer activity of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives bearing chromone moiety.