A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.
McGuire, Helen M; Vogelzang, Alexis; Ma, Cindy S; Hughes, William E; Silveira, Pablo A; Tangye, Stuart G; Christ, Daniel; Fulcher, David; Falcone, Marika; King, Cecile.
; 34(4): 602-15, 2011 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-21511186
The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.
Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells.
IL-21 receptor is critical for the development of memory B cell responses.
IL-21: an executor of B cell fate.
Human IL-21 and IL-21R deficiencies: two novel entities of primary immunodeficiency.
IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection.
Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.
Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.
A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice.