Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models.

Mesaros, Eugen F; Burke, Jason P; Parrish, Jonathan D; Dugan, Benjamin J; Anzalone, Andrew V; Angeles, Thelma S; Albom, Mark S; Aimone, Lisa D; Quail, Matthew R; Wan, Weihua; Lu, Lihui; Huang, Zeqi; Ator, Mark A; Ruggeri, Bruce A; Cheng, Mangeng; Ott, Gregory R; Dorsey, Bruce D.
Bioorg Med Chem Lett; 21(1): 463-6, 2011 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-21074994