Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors.
Prabhakaran, Jaya; Majo, Vattoly J; Milak, Matthew S; Kassir, Suham A; Palner, Mikael; Savenkova, Lyudmila; Mali, Pratap; Arango, Victoria; Mann, J John; Parsey, Ramin V; Kumar, J S Dileep.
Bioorg Med Chem Lett
; 20(12): 3499-501, 2010 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-20494576
Evaluation of [<sup>18</sup> F]BR420 and [<sup>18</sup> F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer.
Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4).
Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease.
Straightforward entry to pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones and their ADME properties.
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
Synthesis and characterization in monkey of [11C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors.
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine.