Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.
McGuire, Helen M; Vogelzang, Alexis; Hill, Natasha; Flodström-Tullberg, Malin; Sprent, Jonathan; King, Cecile.
Proc Natl Acad Sci U S A
; 106(46): 19438-43, 2009 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-19880748
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
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Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.
Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex.
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Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol.
Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function.
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Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation.