Alteration of the carbohydrate binding specificity of verotoxins from Gal alpha 1-4Gal to GalNAc beta 1-3Gal alpha 1-4Gal and vice versa by site-directed mutagenesis of the binding subunit.
Tyrrell, G J; Ramotar, K; Toye, B; Boyd, B; Lingwood, C A; Brunton, J L.
Proc Natl Acad Sci U S A
; 89(2): 524-8, 1992 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-1731324
Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood-brain barrier endothelial cells.
AB5 Preassembly Is Not Required for Shiga Toxin Activity.
Baicalin inhibits the lethality of Shiga-like toxin 2 in mice.
Sensitive detection of Shiga Toxin 2 and some of its variants in environmental samples by a novel immuno-PCR assay.
Shiga-like toxin-based high-efficiency and receptor-specific intracellular delivery system for a protein.
Ultrasensitive detection of Shiga toxin 2 and its variants in Shiga toxin-producing Escherichia coli strains by a time-resolved fluorescence immunoassay.
Alteration of the glycolipid binding specificity of the pig edema toxin from globotetraosyl to globotriaosyl ceramide alters in vivo tissue targetting and results in a verotoxin 1-like disease in pigs.
The crystal structure of shiga toxin type 2 with bound disaccharide guides the design of a heterobifunctional toxin inhibitor.
Sialic acid linkage in glycosphingolipids is a molecular correlate for trafficking and delivery of extracellular cargo.
Identification of a peptide-based neutralizer that potently inhibits both Shiga toxins 1 and 2 by targeting specific receptor-binding regions.