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The Impact of Human Papillomavirus Catch-Up Vaccination in Australia: Implications for Introduction of Multiple Age Cohort Vaccination and Postvaccination Data Interpretation.

Drolet, Mélanie; Laprise, Jean-François; Brotherton, Julia M L; Donovan, Basil; Fairley, Christopher K; Ali, Hammad; Bénard, Élodie; Martin, Dave; Brisson, Marc.
J Infect Dis; 216(10): 1205-1209, 2017 Dec 05.
Artigo em Inglês | MEDLINE | Out 2017 | ID: mdl-28968800
Resumo: We used transmission-dynamic modeling to estimate the added effectiveness of vaccinating multiple cohorts of females (12-26 years) in Australia compared with the theoretical introduction of routine-only (12-13 years) vaccination. Our results suggest that vaccinating multiple cohorts produced markedly faster direct/herd effects, and it added benefits that last for 20-70 years. Furthermore, the number needed to vaccinate to prevent 1 anogential warts (AGW) case or cervical cancer (CC) was similar for routine + catch-up (AGW = 9.9, CC = 678) and routine-only vaccination (AGW = 9.9, CC = 677), thus providing similar levels of efficiency per person vaccinated.