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Plasma concentrations of isoniazid and rifampin are decreased in adult pulmonary tuberculosis patients with diabetes mellitus.

Babalik, Aylin; Ulus, Ismail Hakki; Bakirci, Nadi; Kuyucu, Tulin; Arpag, Huseyin; Dagyildizi, Lale; Capaner, Esen.
Antimicrob Agents Chemother; 57(11): 5740-2, 2013 Nov.
Artigo em Inglês | MEDLINE | Ago 2013 | ID: mdl-23979746
Resumo: Plasma isoniazid and rifampin concentrations, but not pyrazinamide and ethambutol concentrations, were decreased by about 50% (P < 0.05) in diabetic pulmonary tuberculosis patients. The prevalences of subnormal plasma isoniazid, rifampin, pyrazinamide, and ethambutol concentrations were 49% or 100% (P < 0.01), 66% or 100% (P < 0.05), 30% or 50% (P = 0.198), and 32% or 21% (P = 0.742) in nondiabetic or diabetic tuberculosis patients, respectively. These data show that plasma concentrations of isoniazid and rifampin were greatly reduced in diabetic tuberculosis patients.